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Also in the eighties, Grier performed in the stage play "Fool for Love" written by the Oscar-nominated actor & Pulitzer Prize-winning dramatist Sam Shepard.Shepard's play was adapted for the screen in 1985; See Fool for Love (1985).Her early films such as Women in Cages (1971) and The Big Doll House (1971) were filmed in the Philippines.While there she contracted a deadly tropical disease and nearly died.

After 2001, she continued recording verses for herself and other artists but did not release any albums; she left the Def Jam label in 2003, thus canceling the release of her Ill Na Na 2 album.

However, she returned to the label in January 2005 after then-Def Jam president and CEO Jay-Z signed her back to begin work on her new album Black Roses.